Gbp2b macrophage
WebThe responders exhibited a dominant population of macrophages with an M1-like signature, ... including those of GBP2 (4-fold), GBP2b (50.6-fold), GBP3, GBP4, GBP5, GBP6, GBP7, GBP8, and GBP9 on CD45 + cells, … WebM2b, a subtype of M2 macrophages, has attracted increasing attention over the past decade due to its strong immune-regulated and anti-inflammatory effects. A wide variety …
Gbp2b macrophage
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WebMay 9, 2024 · PDF Mycobacterium bovis is a major cause of animal tuberculosis that is also highly dangerous to human health. Autophagic isolation and degradation of... Find, read and cite all the research ... WebGBP2b was identified for further study. (a) Venn diagram shows the overlap between 6 h and 24 h up-and down-regulated genes (log 2Fc > 4.5). (b) The mRNA levels of ten genes from these 35 genes ...
WebGBP2. Interferon-induced guanylate-binding protein 2 is a protein that in humans is encoded by the GBP2 gene. [5] [6] GBP2 is a gene related to the superfamily of large GTPases which can be induced mainly by interferon gamma. [7] WebJan 26, 2024 · To investigate the role of Gbp1 in the regulation of macrophage polarization and function, we established stable Gbp1 Kd macrophage cell lines using the pLKO.1-Puro lentivector system sub …
WebGBP2b-specific siRNA was applied to down-regulate GBP2b expression in BMDMs and RAW264.7 cell infection models, to investigate whether GBP2b is involved in the autophagy regulation in mouse macrophages induced by M. bovis. The knockdown efficiency was detected by Western blot and qRT-PCR after siRNA transfection for 48 h. WebOct 10, 2024 · Those cells are distinct from classically characterized M1 and M2 macrophages, as they secrete high levels of TNFα, IL-6, and IL-1β, three typical M1 macrophage-derived cytokines (Wu et al, 2024). In fact, …
WebChemical compound and disease context of Gbp1. Furthermore, LPA-induced p42mapk activation involved a pertussis toxin-sensitive guanylate nucleotide-binding protein, whereas tyrosine phosphorylation of p125FAK in response to LPA was not prevented by pretreatment with pertussis toxin [12]. The lymphoma transmembrane glycoprotein GP85 ( CD44) is ...
WebFeb 21, 2024 · We found that expression of Gbp2b/Gbp1 and Gbp5 is under strong genetic control involving in some strains also trans-regulation both in uninfected and L. major … organize freezer breastmilkWebAlveolar macrophage apoptosis induced by Mycobacterium tuberculosis (Mtb) plays a significant role in mediating the pathogenesis of tuberculosis. There is growing evidence … organize friends on facebookWebGbp2b (67.4 cM) on mouse Chromosome 3 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wildtype strains. organize french door refrigeratorsWebMay 16, 2024 · For in vitro validation, the RAW264.7 cell line was transfected with GBP2b-specific small interfering RNA and GBP2b plasmid expression vector. Cellular experimental studies confirm that GBP2b was a novel regulatory molecule that promotes M1 macrophage polarization during M. bovis infection and was also an antimicrobial protein … organize freezer with cardboardWebInterferon-induced GTPases [guanylate-binding proteins (GBPs)] play an important role in inflammasome activation and mediate innate resistance to many intracellular pathogens, but little is known about their role in … organize freezer shelvesWebNov 11, 2024 · Validation of similar macrophage pathogenesis in patients will further promote the clinical usage of niclosamide for endometriosis treatment. ... Gbp2b, C1qb, Prdx5, and Gngt2 (p < 6.8e-32; Fig. 5a). organize from lowest to highestWebAug 3, 2016 · Toxoplasma gondii is a worldwide spread pathogen which can infect all tissues of its host. The transcriptomic responses of infected brain and spleen have been reported. However, our knowledge of the global transcriptomic change in infected liver is limited. Additionally, T. gondii infection represents a highly dynamic process involving … organize french door refrigerator