Web27 de out. de 2024 · To further study the role of NLRP3 inflammasomes in aconitine‐induced cardiomyocyte damage, the NLRP3 inhibitor MCC950 was added to the aconitine‐treated H9c2 cells.38, 39, 40 The cleavage of pro‐Caspase‐1 and pro‐IL‐1β and expression of NLRP3 after aconitine incubation were severely suppressed by MCC950 … WebAconitine(Acetylbenzoylaconine) is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of …
Aconitine – A promising candidate for treating cold and …
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Diterpenoid Alkaloids as Antidotes to Aconitine-Type Neurotoxin ...
Web6 de mai. de 2009 · Abstract. Introduction. Aconitine and related alkaloids found in the Aconitum species are highly toxic cardiotoxins and neurotoxins. The wild plant (especially the roots and root tubers) is extremely toxic. Severe aconite poisoning can occur after accidental ingestion of the wild plant or consumption of an herbal decoction made from … WebThe injection volume was 10 μL and a total run time of 10 min was used. All aspects of system opera- ... Aconitine poisoning due to Chinese herbal medicines: a review. Vet Hum Toxicol 36: 452-455. 7. Ito K, Tanaka S, Funayama M, Mizugaki M (2000). Distribution WebDownload : Download high-res image (757KB) Download : Download full-size image; ... 60 min after intraperitoneal injection of aconitine (0.0500 mg/kg, n = 6 mice/group). (F) Time of licking feet within 30 min after the intraplantar injection of menthol (100 mM, 10 µL) 60 min after intraperitoneal injection of aconitine (0.0500 mg ... devil\u0027s cigar hissing