Tīmeklis2012. gada 1. jūl. · Laminin G domains (LamG) are found only at the C-terminus of the α-type chains and appear to be the main sites for interaction between the … Tīmeklis2024. gada 1. jūn. · A unique O-mannose-linked glycan on the transmembrane protein dystroglycan binds a number of extracellular matrix proteins containing laminin G-like (LG) domains. The dystroglycan-matrix interaction is essential for muscle function: disrupted biosynthesis of the matrix-binding modification causes several forms of …

The Requirement of the Glutamic Acid Residue at the Third …

TīmeklisThe EGF-like domain is an evolutionary conserved protein domain, which derives its name from the epidermal growth factor where it was first described. It comprises about 30 to 40 amino-acid residues and has been found in a large number of mostly animal proteins. Most occurrences of the EGF-like domain are found in the extracellular … Tīmeklis2011. gada 3. marts · Crystallization of a laminin short-arm fragment. As LN domains cannot be produced in isolation (Ettner et al, 1998; Odenthal et al, 2004), we produced a series of laminin short-arm fragments containing the LN domain, followed by 2–4 LEa domains (supplementary Table S1 online).The best crystals we obtained were of an … crewbidd

Basal lamina strengthens cell membrane integrity via the laminin G ...

TīmeklisPrevious studies demonstrated that laminin 1 (L1) is critical for intact salivary cell cluster formation and organization. However, the full L1 sequence is not suitable for clinical applications, as each protein domain may contribute to unwanted effects, such as degradation, tumorigenesis, and immune responses that, when compounded, … Tīmeklis2009. gada 4. aug. · Integrin α7β1 was reported to bind laminin only, but α-DG has been shown to bind a variety of basal lamina proteins containing the LG domains, such as laminin (9, 38), perlecan , and agrin . In addition, considerable data showed that integrin α7β1 primarily functions at the myotendinous junctions ( 20 , 24 , 39 , 40 ) … The exact function of the Laminin G domains has remained elusive, and a variety of binding functions has been ascribed to different Laminin G modules. For example, the laminin alpha1 and alpha2 chains each have five C-terminal laminin G domains, where only domains LG4 and LG5 contain binding sites for … Skatīt vairāk Laminins are a family of glycoproteins of the extracellular matrix of all animals. They are major components of the basal lamina (one of the layers of the basement membrane), the protein network foundation for most cells and organs. … Skatīt vairāk In humans, fifteen laminin trimers have been identified. The laminins are combinations of different alpha-, beta-, and gamma-chains. • Five … Skatīt vairāk Dysfunctional structure of one particular laminin, laminin-211, is the cause of one form of congenital muscular dystrophy. Laminin-211 is … Skatīt vairāk Laminins contain several conserved protein domains. Laminin I and Laminin II Laminins are … Skatīt vairāk Laminins form independent networks and are associated with type IV collagen networks via entactin, fibronectin, and perlecan. … Skatīt vairāk Together with other major components of the ECM, such as collagens and fibronectin, laminins have been used to enhance mammalian cell culture, especially in the case of … Skatīt vairāk • Laminin domain I: all laminin alpha chains (LAMA1, LAMA2, LAMA3, LAMA4, LAMA5) • Laminin domain II: all laminin alpha chains (LAMA1, LAMA2, LAMA3, LAMA4, LAMA5) Skatīt vairāk buddhism sacred spaces