Phosphatase tensin-type domain
Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been … See more PTEN protein acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN specifically catalyses the dephosphorylation of the 3` phosphate of the See more The structure of the core of PTEN (solved by X-ray crystallography, see figure to the upper right ) reveals that it consists primarily of a phosphatase domain, and a C2 domain: the phosphatase domain contains the active site, which carries out the See more PTEN inhibitors Bisperoxovanadium compounds may have a neuroprotective effect after CNS injury. PTEN is inhibited by See more PTEN (gene) has been shown to interact with: • CSNK2A2, • CSNK2A1, • MAGI3 • MVP, • NEDD4, See more Cancer PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. A number of studies … See more Cell lines with known PTEN mutations include: • prostate: LNCaP, PC-3 • kidney: 786-O • glioblastoma: U87MG • breast : MB-MDA-468, BT549 See more • Multiple hamartoma syndrome See more WebJan 2, 2024 · Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) encodes a 403-amino acid protein with an amino-terminal domain that shares sequence homology with the actin-binding protein tensin and the putative tyrosine-protein phosphatase auxilin.Crystal structure analysis of PTEN has revealed a C2 domain that binds to …
Phosphatase tensin-type domain
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WebEnables lipid phosphatase activity. Acts upstream of or within several processes, including lifelong otolith mineralization; negative regulation of angiogenesis; and phosphatidylinositol dephosphorylation. Predicted to be located in PML body and cytoplasm. WebJul 27, 2015 · PTEN is composed of four structural domains [PIP2-binding domain (aa 1–13), a catalytic tensin-type phosphatase domain (aa 14–185), a C2 tensin-type domain, which binds phospholipids (aa 190–350), the carboxy-terminal tail of the protein (aa 350–400), and a PDZ-binding domain (aa 401–403).
WebChain A, Tensin-like C1 domain-containing phosphatase (human) Protein Target - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW … WebJul 9, 2024 · • Phosphatase and Tensin Homolog deleted on Chromosome 10 (PTEN) is a dual phosphatase with both protein and lipid phosphatase activities. • PTEN reduces the level of PI-3, 4, 5-P 3, a critical 2nd …
WebBreast cancer has been attributed to be the second most common malignancy in females worldwide after skin cancer associated with a significantly high mortality rate. Tumor suppressor genes have an indispensable role in maintaining genomic integrity
WebPhosphatase and tensin homolog (PTEN) is a tumor suppressor and component of PI3K-AKT-mTOR signaling. Cowden syndrome is an inherited, autosomal dominant phenotype …
WebGene Variant Descriptions. PTEN H93Q lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H93Q demonstrates Pten protein stability similar to wild-type protein ( PMID: 32350270, PMID: 32366478 ), however, results in a partial loss of ability to rescue spheroid formation ( PMID: 32366478 ), fails to suppress Akt ... greg fosse insuranceWebContains 1 phosphatase tensin-type domain. 结构域 The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this binding is important for its tumor suppressor function. greg foss youtubeWebMar 21, 2024 · The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. ... interacts (via C2 tensin-type domain) with p85 but, following growth factor stimulation, PTEN is … greg foster facebook postWebPTEN H93Y lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H93Y demonstrates loss of phosphatase activity ( PMID: 10866302 , PMID: … greg foughty obituary ohioWeb132 rows · Apr 4, 2024 · Summary. This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains … greg foxsmith lawyerWebTensins constitute an eukaryotic family of lipid phosphatases that are defined by the presence of two adjacent domains: a lipid phosphatase domain and a C2-like domain. The … greg foss net worthWebIPR014020 - Tensin_phosphatase_C2-dom Pfam Domains: PF08416 - Phosphotyrosine-binding domain PF10409 - C2 domain of PTEN tumour-suppressor protein PF00017 - SH2 … greg fox motorcycle accident